Artemisinin 99% (wormwood Extract)

Changsha Natureway Co., Ltd. is a professional manufacturer of herbal extracts and green tea extracts in China.
We gained ISO9001 and GMP certificate.
Contact: Linda
Skype: linda01123
Tel: 86 731 2866 768
Fax: 86 731 2967875
E-mail: lind23@21cn.com
Http://www.herbingredient.com




1. Artemisinin 99%
 Color: Fine white or crystal powder
 Latin name: Artemisia annua L.
 Active ingredients: artemisinin
 Specifications: 99% artemisinin
 Solubility: Soluble in ethanol
 Plant used: natural wormwood dried leaf
 Packing: 25kg/drum
 Annual availability: 30 MT of above mentioned specifications.
2. Chemical structure of artemisinin:
3. Brief description:

Artemisinin was originally developed in 1972 in China (Chinese Institute of material medicine) from the plant Artemisia annua L (sweet wormwood), a sesquiterpene lactone (emperical formula C15 H22 O5. Artemisinin is the active ingredient in qinghao, a Chinese herbal tea that have been used for 150 years to treat malaria and haemorrhoids. It grows in the wild in China and now has been found to grow in other parts of the world too, though the species may vary a bit. Locally, it is prepared as an infusion of the dried leaves.

Derivatives of Artemisinin are; artemether, artesunate, arteether and artelinate. Artemisinin and these compounds are quickly converted to their active plasma metabolite, dihydroartemisinin, which is the chemical with the anti-malarial activity.
Artemisinin, artemether and arteether are water insoluble, artesunate and artelinate are water-soluble.

4. Effects of artemisinin
 The use for malaria
This treatment for malaria was, however, lost over time. It was only rediscovered in an archeological dig in the 1970s where its medicinal use was found in a recipe inside a tomb. The formula was dated back to 168 B.C. where the Chinese chemist isolated the primary active ingredient from the leafy portion of plant called A. annua L.
In 1972, scientists in the West called this crystalline compound "qinghaosu" or "artemisinin". Since then, studies in China and Vietnam have confirmed that artemisinin is a highly effective compound with close to 100 percent response rate for treating malaria. It has the ability to destroy the malaria parasite by releasing high doses of free radicals that attack the cell membrane of the parasite in the presence of high iron concentration. In fact, over one million malaria patients have been cured via this method. Their symptoms also subsided in a matter of days.
However, the treatment using this herb to treat malaria is not approved for use in the U.S.A due to the concern that it has a 21 percent recrudescent rate. Scientists believe that this is more likely due to patients not taking the compound for a long period. Many of them actually stop taking it as soon as their symptoms subside.
Artemisinin comes in a few derivatives, including the oil soluble artemether, which has been found to induce neurotoxic symptoms in animals in high dose (but not reported in humans). For those who are technically inclined, the activities of all artemisinin derivatives are dependent on their internal endoperoxide bridge. It is therefore a close relative of hydrogen peroxide therapy. While the exact mechanism is still under intense research, it has been shown that this herb works via highly reactive oxygen-based free radicals that becomes activated in the presence of iron. Iron is an oxidant, and our body tries to protect us from excessive iron moving it to a binded state such as hemoglobin and enzymes. The malaria parasite accumulates iron by infecting iron-rich red blood cell. Excessive iron that is spilled onto the surrounding tissues will activate the artemisinin to generate a burst of free radicals that attack the iron rich cells, killing the parasite in the process.
In other words, this compound works well in an iron rich environment (remember that malaria lives in the red blood cell rich in iron) through the release of free radicals that serve to damage the malaria organism. It is also interesting to note that drugs known to work by enhancing oxygen radical effects such as doxorubicin can enhance the effects of artemisinin.
For malaria, there is no resistance nor toxicity at the dosage of 3 grams (about 50mg/kg), administered over a 3 to 5 day period. It is especially useful in the treatment of drug resistant malaria.
Outside of the United States, artemisinin is the number one natural herb used for malaria treatment.
 The use for cancer
So far, the most extensive study on the use of Artemisinin as an anti-cancer agent was carried out by bioengineering scientists Drs Narenda Singh and Henry Lai of the University of Washington. This study was reported in the Journal Life Science (70 (2001): 49-56).
Iron is required for cell division, and it is well known that many cancer cell types selectively accumulate iron for this purpose. Most cancers have large number of iron attracting transferring receptors on their cell surface compared to normal cells. In laboratory studies of radiation, resistant breast cancer cells that has high propensity for accumulating iron revealed that artemisinin has 75 percent cancer cell killing properties in a 8 hours and almost 100 percent killing properties within 24 hours when these cancer cells are "pre-loaded" with iron after incubation with holotransferrin. On the other hand, the normal cells remained virtually unharmed. Another study showing the effectiveness of artesunate in treatment of cancer was also published in Oncology (April 2001: 18(4): 767-73).
The fact that iron content of cancer cells is high has also been used in another anti-cancer therapy called Zoetron therapy, where iron containing cancer cells are induced into motion using a magnetic device to induce resonance. Resonance generate heat. Cancer cells are more sensitive to heat compared to normal healthy cells. When cancer cells are heated to a certain temperature, they die while normal cells still survive.
Artemisinin is effective against a wide variety of cancers as shown in a series of successful experiments. The most effective is leukemia and colon cancer. Intermediate activities were also shown against melanoma, breast, ovarian, prostate, CNS and renal cancer. Although artemisinin is insoluble in water, it is able to cross the blood brain barrier (the water soluble artesunate is the weakness among the derivates) and may be particularly suitable for curing brain tumors, together with Poly-MVA (an metalo-vitamin)
In laboratory studies, iron needs to be added to enhance the effects of artemisinin. Within the human body, no such addition is necessary, as iron already exist in the body. It can also be taken orally and therefore high doses are not required. Some people believe that as nitrogen (tertiary amine) is absent in ART, cancer cells cannot get rid of it once it enters into the cancer cell. As a result, ART stays in the cell much longer.
In addition to the high affinity for iron in aggressive cancer cell types, most cancer cells also lack the enzyme catalayse and gutathione peroxidase. Catalayse breaks down hydrogen peroxide. A low catalayse content means a higher hydrogen peroxide load, which can release superoxide free radicals when properly stimulated to do so. This is in fact one common mechanism among chemotherapeutic agents as well as vitamin C. These traits make cancer cells more susceptible to oxidative damage as compare to normal cells in the presences of hydrogen peroxide. For this reason, administration of vitamin C in high dose is acceptable, although a gap of 2-3 hours is preferred.
According to Dr Rowen , a naturally oriented medical doctor and editor of the medical newsletter " Second Opinion" , the Hoang family of physicians in Vietnam had used arteminisin in the treatment of cancer for years. They have reported that, over a 10-year period, more than 400 patients were treated with artemisinin in conjunction with a comprehensive anti-cancer program with 50 to 60 percent long-term remission rate. The safety record of artemisinin has well been studied for over 25 years. No significant toxicity in short-term use for malaria at high dose of up to 70 mg/kg per day has been reported.
Artemisinin is not a stand-alone chemotherapeutic agent. A combination of nutritional supplements (such as green tea, CoQ10 and pancreatic enzyme) as well as a good anti-cancer diet is required.
ART may be administered orally, with a 32 percent bioavailability as compared to injections. It is highly bound to membranes. Laboratory measurement of its serum level is therefore not exact.

5. Our products:
Artemisinin 99% artemisinin
Alfalfa extract 5% flavonoids
Alfalfa extract 7:1
Angelica extract 1% ligustilide
Astragalus root extract 0.2% Flavone & 16% Polysacchrides
Astragalus root extract 50% polysaccharides
Astragalus root extract 4:1
Banaba leaf extract 1% corosolic acid
Banaba leaf extract 3% corosolic acid
Barley grass juice powder 20:1
Bilberry extract 5:1
Bilberry extract 10% anthocyanidins
Bilberry extract 15% anthocyanidins
Bilberry extract 25% anthocyanidins
Bilberry juice (frozen) juice
Blueberry extract 25% anthocyanidins
Black currant extract 25% anthocyanidins
Bitter melon extract 10:1
Bitter melon extract 30:1
Black tea extract 25% polyphenols
Cat's claw extract 4:1
Cat's claw extract 4% alkaloids
Citrus aurantium extract 10% synephrine
Citrus aurantium extract 30% synephrine
Citrus aurantium extract 95% synephrine
Cinnamon bark extract 10:1
Cinnamon bark extract 20:1
Cordyceps Extract 4:1
Cordyceps Extract 40% polysaccharides
Ecdysterone 90% ecdysterone
Eyebright extract 4:1
Turmeric extract 15% curcumin
Turmeric extract 90% curcumin
Turmeric extract 95% curcumin
Echinacea purpurea extract 4% phenolics
Echinacea purpurea extract 4% phenolics
Echinacea purpurea extract 6% phenolics
Echinacea purpurea extract 10% phenolics
Ginkgo biloba leaf extract 24% Ginkgoflavoglycosides / 6% Terpene Lactories / Ginkgolic Acid <5ppm
Ginkgo biloba leaf extract 24% Ginkgoflavoglycosides / 6% Terpene Lactories / Ginkgolic Acid <1ppm
Ginkgo biloba leaf extract 24% Ginkgoflavoglycosides / 6% Terpene Lactories / Ginkgolic Acid <1ppm
Guarana extract Caffeine 22%
Guarana extract Caffeine 10%
Grape seed extract 95% proanthocyanidins
Green tea extract 40% polyphenols / 10% EGCG
Green tea extract 40% polyphenols / 12% EGCG
Green tea extract 40% polyphenols / 15% EGCG
Green tea extract 50% polyphenols / 30% catechins / <1% caffeine
Green tea extract 75% polyphenols / 50% catechins / 30% EGCG
Green tea extract 90% polyphenols / 70% catechins / 40% EGCG
Green tea extract 95% polyphenols / 80% catechins / 45% EGCG / <1% caffeine
Green tea extract 98% polyphenols / 80% catechins / <1% caffeine
Green tea extract 99% polyphenols / 85% catechins / <0.5% caffeine
Green tea extract 85% catechins / 50% EGCG/ <1% caffeine
Green tea extract 85% catechins / 60% EGCG/ <0.5% caffeine
Green tea extract 20% L-theanine
Green tea extract 30% L-theanine / <2% caffeine
Green tea extract 98% L-theanine
Green tea extract 20% polysaccharides
Instant black tea extract 25% polyphenols
Instant green tea extract 40% polyphenols
Instant Oolong tea extract 25% polyphenols
Instant jasmine tea extract 40% polyphenols
Instant Pu'er tea extract 25% polyphenols
Jujube extract 5:1
Kudzu root extract 40% isoflavones
Kudzu root extract 50% isoflavones
Kudzu root extract 60% isoflavones
Kudzu root extract 80% puerarine
Luo han guo extract 12:1
Luo han guo extract 80% mogrosides
Luo han guo extract 25% Mogroside Ⅴ
Lycium extract 15% polysaccharides
Lycium extract 40% polysaccharides
Macleaya cordata extract 60% alkaloids
Macleaya cordata extract 40% sanguinarine
Macleaya cordata extract 20% alkaloids
Magnolia bark extract 40% Magnolol+ Honokiol
Magnolia bark extract 90% Magnolol+ Honokiol
Magnolia bark extract 95% Magnolol+ Honokiol
Marigold extract 5% lutein
Marigold extract 10% lutein
Milk thistle extract 80% silymarin / 30% silybin
Milk thistle extract 80% silymarin / 35% silybin
Milk thistle extract 80% silymarin / 40% silybin
Milk thistle extract 60% silybin
Panax ginseng extract 10% ginsenosides
Panax ginseng extract 50% ginsenosides
Panax ginseng extract 80% ginsenosides
Panax ginseng extract powder / 4% ginsenosides
Passion flower extract 4:1
Passion flower extract 4% flavonoids
Pumpkin seed extract 4:1
Pumpkin seed extract 20% polysaccharides
Red Rice Yeast 4:1
Red Rice Yeast 0.5% Lovastatin
Red Rice Yeast 1.0% Lovastatin
Red Rice Yeast 1.5% Lovastatin
Reishi mushroom extract 4:1
Reishi mushroom extract 10% polysaccharides / 4% Triterpenoids
Reishi mushroom extract 30% polysaccharides
Rhodiola crenulata extract 1% salidrosides
Rhodiola crenulata extract 2% salidrosides
Rhodiola crenulata extract 3% salidrosides
Rhodiola rosea extract 40% poly / 1% rosavins / 1% salidrosides
Rhodiola rosea extract 45% poly / 2% rosavins
Rhodiola rosea extract 50% poly / 3% rosavins
Rhodiola rosea extract 50% poly / 5% rosavins
Rosemary extract 2.5% rosmarinic acid
Rosemary extract 25% carnosic acid
Soy bean extract 40% soy isoflavones
Soy bean extract 60% soy isoflavones
Stevia extract 80% steviosides (de-bitter)
Stevia extract 90% steviosides / RA>40%
Stevia extract 90% steviosides / RA>60%
Stevia extract 90% steviosides / RA>80%
Stevia extract 95% steviosides
Scutellaria root extract 78% baicalin
Scutellaria root extract 80% baicalin
Scutellaria root extract 90% baicalin
Scutellaria root extract 95% baicalin
Siberian Ginseng extract 0.8% Eleutherosides B + E
Siberian Ginseng extract 1.2% Eleutherosides B + E
Tomato juice extract 1% lycopene
Tomato juice extract 3% lycopene
Tomato juice extract 5% lycopene
Tomato juice extract 6% lycopene
Tomato juice extract 10% lycopene
Wild yam extract 8% saponin on diosgenin
Wild yam extract 16% saponin on diosgenin
Ziziphi jujuba extract 4:1

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Changsha Natureway Co.,ltd is a professional manufacturer of herbal extracts and green tea extracts in China. We gained ISO9001 and GMP certificate.

Contact:Ms.Linda
Tel: +86 731 2866 768
Fax: +867312967 875
skype:linda01123
Email:linda23@21cn.com
Address:No 1012 Xiongju city east North MaWangdui Road.Changsha Hunan
Http://www.herbingredient.com