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Hirudin Extract

Posted at: Offers to Sell and Export | Posted on: Mon 13 Aug, 2007 3:30 am | Product Category: Spices or extracts [3400]
hirudin extract
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CAS #: 113274-56-9

Molecular formula: C66H93N13O25

Molucular weight: 1468.53


White fine powder

Purity: ≥98%

Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. This is fundamental for the leeches alimentary habit of hematophagy, since it keeps the blood flowing after the initial phlebotomy performed by the worm on the host's skin.A key event in the final stages of blood coagulation is the convertion of fibrinogen into fibrin by the serine protease enzyme thrombin.[4] Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal blood circulation is antithrombin III.[3] Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the pro-coagulant activity of thrombin.Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits only the activity of thrombin forms with a specific activity against fibrinogen.[3] Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.

Company Contact:

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Contact Name: Ye Lixia
Company Name: Shaanxi Sciphar Biotechnology Co., Ltd.
Email: Email
Tel: +86-29-88353228 , +86-29-88389752 , +86-29-88353265
Fax: +86-29-88389961
Street Address: No.11 Tangxing Road, Hi-
Tech Development Zone, Xian city, Shaanxi
Province, China Postcode: 710075
Website: http://www.sciphar.com
Member name: wwwscipharcom
Country: China-CN China
Member Since: 13 August 2007
Total Leads: 58 wwwscipharcom Import Export Business Leads
Business focus: Natural Herb Extract, Ingredients, Intermediates, Chemical, Pharmaceutical
Verify: Safe Import Export Tips
Product Category: Spices or extracts [3400]

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