This immunoassay kit allows for the
specific measurement of human Anti-C1q antibody, C1q-Ab concentrations in cell culture supernates, serum, and plasma.
Anti-Clq antibodies is a marker of lupus activity. Serum anti-C1q levels in patients with systemic lupus erythematosus (SLE), especially in patients with nephritis.Anti-C1q antibodies seem to correlate with active renal SLE. One study showed that anti-Clq antibodies correlated with the proliferative forms of lupus nephritis and the rise in titres of anti-C1q preceded the development of clinical activity of disease by 6 months with a positive predictive value of 50 per cent. Another study reported a correlation between the ongoing production of IgG anti-C1q and proliferative lupus nephritis. Anti-Clq antibody is not specific to SLE; in fact, it has been described in rheumatoid vasculitis, urticarial vasculitis, idiopathic membranoproliferative glomerulonephritis and IgA nephropathy.
This assay employs the quantitative sandwich enzyme immunoassay technique. A monoclonal
antibody specific for anti-C1q-Ab has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any anti-C1q-Ab present is bound by the immobilized antibody. An enzyme-linked polyclonal antibody specific for anti-C1q-Ab is added to the wells. Following a wash to remove any unbound antibody-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of anti-C1q-Ab bound in the initial step. The color development is stopped and the intensity of the color is measured.
Contact Name: Lucia
Company Name: Wuhan Eiaab Science Co., Ltd
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East Lake Hi-tech Zone, Wuhan, China
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