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Phyllanthus Niruri - Leading Indian Herb Supplier- Raw Herbs And Herbal Products Medicinal Plants
Posted at: TradersCity --> Offers to Sell and Export
Posted on: Mon 14 Jan, 2008 6:02 am
Phyllanthus niruri has been found to exhibit marked inhibitory effect on hepatitis B virus evident by its exhaustive utility in cases of chronic jaundice. However, till date, research has not been focused on identification and validation of active pharmacophores of Phyllanthus niruri responsible for the reported inhibitory effect of its aqueous extract on anti-human immunodeficiency virus. The present investigation examines the anti-HIV effects of the alkaloidal extract of Phyllanthus niruri in human cell lines. The inhibitory effect on HIV replication was monitored in terms of inhibition of virus induced cytopathogenecity in MT-4 cells. The alkaloidal extract of Phyllanthus niruri showed suppressing activity on strains of HIV-1 cells cultured on MT-4 cell lines. The CC50 for the extract was found to be 279.85 microgmL(-1) whereas the EC50 was found to be 20.98 microgmL(-1). Interestingly the Selectivity Index (SI) was found to be 13.34, which showed a clear selective toxicity of the extract for the viral cells. The alkaloidal extract of Phyllanthus niruri was thus found to exhibit sensitive inhibitory response on cytopathic effects induced by both the strains of human immunodeficiency virus on human MT-4 cells in the tested concentrations.
Phyllanthus niruri Linn has been used in Ayurvedic medicine for over 2,000 years and has been used in wide number of traditional ailments such as jaundice, gonorrhea, frequent menstruation, and diabetes and topically as a poultice for skin ulcers, sores, swelling, and itchness. The plant has a role in liver disorders due to its febrifuge, antiseptic, astringent, stomachic, deobstruent and diuretic actions. It corrects GIT troubles like dyspepsia, colic, diarrhea and dysentery and tones the GIT tract back to function. The young shoots of the plant are administered in the form of an infusion for the treatment of chronic dysentery. Phyllanthus niruri primarily contains lignans (e.g., phyllanthine and hypophyllanthine), alkaloids, and bioflavonoids (e.g., quercetin). Phyllanthus blocks DNA polymerase, the enzyme needed for the hepatitis B virus (HBV) to reproduce. It has been found to inhibit DNA polymerase of HBV and binds to HbsAg, in vitro. The fact that both HBV DNA polymerase inhibitory activity and HbsAg binding activity are present in an isolable component of Phyllanthus niruri served as a harbinger of this research work. While it remains unknown as to which of these ingredients has an antiviral effect, research shows that this herb acts primarily on the liver. This action in the liver confirms its historical use as a remedy for jaundice. A comprehensive research focused on identification of the specific pharmacophore of Phyllanthus niruri remains the need of the hour. The prime objective of this study was thus focused on identification and evaluation of anti-HIV activity of Phyllanthus niruri with a viewpoint to broad base the pharmacological profile of the plant species.
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