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Supply Gypenosides

Posted at: Offers to Sell and Export | Posted on: Mon 13 Aug, 2007 3:27 am |
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CAS #: 52705-93-8

Molecular formula:

Molucular weight:

Formulation: White fine powder

Purity: ≥98%HPLC

Gypenosides isolated from Gynostemma pentaphyllum are widely used in traditional Chinese medicine, with beneficial effects reported in numerous diseases, including inflammation and atherosclerosis, although the mechanism underlying these therapeutic effects is unknown. Because increased nitric oxide (NO) plays a role in these pathological conditions, we investigated whether the pharmacological activity of gypenosides is due to suppression of NO synthesis. The action of gypenosides (GP, saponins of Gynostemma pentaphyllum, a Chinese medicinal herb) as an antioxidant was studied using various models of oxidant stress in phagocytes, liver microsomes and vascular endothelial cells. The results show that GP decreased superoxide anion and hydrogen peroxide content in human neutrophils and diminished chemiluminescent oxidative burst triggered by zymosan in human monocytes and murine macrophages. An increase of lipid peroxidation induced by Fe2+/cysteine, ascorbate/NADPH or hydrogen peroxide in liver microsomes and vascular endothelial cells was inhibited by GP. It was also found that GP protected biomembranes from oxidative injury by reversing the decreased membrane fluidity of liver microsomes and mitochondria, increasing mitochondrial enzyme activity in vascular endothelial cells and decreasing intracellular lactate dehydrogenase leakage from these cells. The extensive antioxidant effect of GP may be valuable to the prevention and treatment of various diseases such as atherosclerosis, liver disease

Company Contact:

No member photo
Contact Name: Ye Lixia
Company Name: Shaanxi Sciphar Biotechnology Co., Ltd.
Email: Email
Tel: +86-29-88353228 , +86-29-88389752 , +86-29-88353265
Fax: +86-29-88389961
Street Address: No.11 Tangxing Road, Hi-
Tech Development Zone, Xian city, Shaanxi
Province, China Postcode: 710075
Website: http://www.sciphar.com
Member name: wwwscipharcom
Country: China-CN China
Member Since: 13 August 2007
Total Leads: 58 wwwscipharcom Import Export Business Leads
Business focus: Natural Herb Extract, Ingredients, Intermediates, Chemical, Pharmaceutical
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