Oleanolic Acid Product Name: Oleanolic Acid
Oleanolic Acid Plant Origin: Olea europaea L.
Oleanolic acid (OA) is a triterpenoid compound that has been shown to protect against a number of hepatotoxicants, and is used in China to treat hepatitis. In the present study, we examined the effect of Oleanolic acid on acetaminophen (AA)-induced acute liver injury in mice and the mechanism(s) of protection. Oleanolic acid pretreatment (25-100 mg/kg s.c. for 3 days) remarkably decreased AA (500 mg/kg i.p.)-induced liver damage in mice, as indicated by decreased serum activities of alanine aminotransferase and sorbitol dehydrogenase, as well as by histopathological observation. Additionally, Oleanolic acid pretreatment mitigated AA (300-450 mg/kg i.v.)-induced depletion in liver glutathione (GSH) content. The protective effect was not evident until 24 hr after a single s.c. injection of Oleanolic acid (300 mg/kg) and lasted for 72 hr. To examine the mechanism of this protection, the biliary and urinary excretion of AA and AA metabolites were measured for 2 hr after AA administration (150 mg/kg i.v.) in bile duct-cannulated mice. Oleanolic acid pretreatment resulted in an increased urinary excretion of AA- glucuronide and a decreased biliary excretion of AA-GSH. Microsomes from Oleanolic acid-pretreated mice, incubated in vitro with AA, produced less benzoquinoneimine intermediate than controls, as determined by the formation of AA-GSH. Hepatic subcellular distribution of [3H] AA to the nuclear fraction was also decreased by Oleanolic acid. Oleanolic acid pretreatment of mice had no influence on liver UDP-glucuronic acid concentration, but increased hepatic glucuronosyltransferase activity toward AA.
1) Oleanolic Acid is used to treat hepatitis.
2) Oleanolic acid (OA) is a triterpenoid compound that has been shown to protect against a number of hepatotoxicants.
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Company Name: Copalyton Chemical Materials Co., Ltd.
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