Natamycin (INN, CAS: 7681-93-8), also known as pimaricin, is a naturally occurring antimicrobial agent
produced by the bacterium Streptomyces natalensis.
Natamycin lacks acute toxicity. In animal studies, the lowest LD50 found was 450 mg/kg. In rats, the LD50 is ≥2300 mg/kg, and doses of 500 mg/kg/day over 2 years caused no detectable differences in survival rate, growth, or incidence of tumors. The metabolites of natamycin also lack toxicity. The breakdown products of natamycin under various storage conditions may have a lower LD50 than natamycin, but in all cases the numbers are quite high. In humans, a dose of 500 mg/kg/day repeated over multiple days caused nausea, vomiting, and diarrhea.
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